The effect of a stabilised oil (Lyprinol®) from green lipped mussel (Perna canaliculus) on pain and Activities of Daily Life in patients with osteoarthritis in knee and/or hip. 
 A Pilot investigation.

Niels Hertz, M.D.
Smedelundsgade 30
DK 4300 Holbæk, Danmark.

APPENDIX

Assessment of functional disability (ADL) with osteoarthritis of the knee and/or hip. (slighty modified from (3)

Pain or discomfort during nocturnal bedrest
On movement or in certain positions
Without movement
1
2
Duration of morning stiffness or pain after getting up
< 15 min.
15 min or more		 1
2
Standing for 30 min increases pain 1
Pain on walking
After walking some distance
Soon after walking		 1
2
Pain or discomfort when getting up from sitting position 1
Maximum distance walked
>1 km, but limited
About 1 km
500-900 m
300-500 m
100-300 m
< 100 m
with 1 walking stick or crutch with
2 walking sticks or crutches 		1
2
3
4
5
6
7
8
Can you
Go up a standard flight of stairs?
Go down a standard flight of stairs?
Squat completely ?
Walk on uneven ground?		 0-2
0-2
0-2
0-2
score: 0 = easy. I = with difficulty, 2 = impossible)

How would you judge your level of pain during the last 3-4 days?
(0 means no pain at all, 10 means worst thinkable pain)

0 1 2 3 4 5 6 7 8 9 10
                     

 
PATIENT
BEFORE TREATMENT
(VAS-pain/ADL)
AFTER 3-4 WEEKS
(2x2 Lyprinol Daily)
AFTER ANOTHER
3-4 WEEKS
(1x2 Lypronol Daily)
1) Female
3/5
2/4
1/2
2) Female
3/7
2/5
1/4
3) Female
8/18
3/15
4/16
4) Female
5/16
3/12
3/11
5) Female
5/13
4/12
6) Female
4/11
2/11
7) Male
8/13
4/5
8) Female
3/5
0/1
9) Male
5/11
2/10
10) Male
8/15
1/6
11) Male
7/9
5/7
12) Female
6/18
13) Male
2.5/8
Nr 1-11 Total
59/123
27/84




ADL = Activities of Daily Life
VAS-Pain score + Impression of pain expressed on a scale from
O (no pain) to 10 (worst possible)

Pain #score (VAS) before and after 3-6 weeks treatment with Lyprinol
(2x2 capsules in 4 weeks, thereafter 1x2 capsules)

  • Patients with X-Ray verified and/or arthroscopiaverified Osteoarthritis in hips and/or knees.
  • Total VAS before: 52
  • Total VAS after : 22

ADL-score before and after 3-6 weeks treatment with Lyprinol
(2x2 capsules in 4 weeks, thereafter 1x2 capsules)

  • Total ADL before: 123
  • Total ADL after: 84

Appendix 1

Doctors form

1)

Date________

Patient (name, cpr number)______________________________

Patient nr.___________________

Osteoarthritis in knee__________ in hip__________

Hb:__________ SR:__________

Length of osteoarthritis app__________ -years.

Lates x-ray. Date________ Joint Diagnose__________

Other Major disease_______________

Global assessment of the joint-disease (very pronounced. pronounced. moderate, minor)________

Eventual reason for exclusion_______________

2)

Date________

Is there any side effects of the treatment ? (which)_______________

Intercurrent disease:_______________

Global assessment (no change, slightly better. much better. slightly worse. much worse)________

3)

Date________

Is there any side effects of the treatment?

Intercurrent disease______________

Global assessment (no change. slightly better. much better. slightly worse. much worse)______

4)

Date________

Is there any side effects of the treatment ?_______________

Intercurrent disease_______________

Global assessment (no change, slightly better, much better, slightly worse much worse)

5)

Date________

Is there any side effects of the treatment ?_______________

Intercurrent disease_______________

Global assessment (no change, slightly better, much better, slightly worse, much worse)________

6)

Date________

Is them any side effects of the treatment ?_______________

Intercurrent disease_______________

Global assessment (no change. slightly better. much better, slightly worse much worse)________